CNOT9 Gene Summary [Human]
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | CNOT9 |
| Official Name | CCR4-NOT transcription complex subunit 9 [Source:HGNC Symbol;Acc:HGNC:10445] |
| Ensembl ID | ENSG00000144580 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 9, cancer/testis antigen 129 |
| Synonyms | 2610007F23Rik, CAF40, CCR4-NOT transcription complex subunit 9, CCR4-NOT transcription complex, subunit 9, CT129, Fl10, RCD-1, RQCD1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- kinase binding
- epidermal growth factor receptor binding
- Cell differentiation family, Rcd1-like
- protein homodimerization
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sex differentiation
- positive regulation of transcription, DNA-dependent
- cytokine-mediated signaling pathway
- positive regulation of epidermal growth factor receptor signaling pathway
- negative regulation of intracellular estrogen receptor signaling pathway
- gene silencing by RNA
- negative regulation of translation
- nuclear-transcribed mRNA poly(A) tail shortening
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytoplasmic mRNA processing body
- cytosol
- macromolecular complex
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein homodimerization activity
- ligand-dependent nuclear receptor transcription coactivator activity
- epidermal growth factor receptor binding
- kinase binding