ACBD3 Gene Summary [Human]
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ACBD3 |
| Official Name | acyl-CoA binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15453] |
| Ensembl ID | ENSG00000182827 |
| Bio databases IDs | |
| Aliases | acyl-CoA binding domain containing 3, PBR- and PKA-associated protein 7 |
| Synonyms | 8430407O11Rik, acyl-CoA binding domain containing 3, acyl-Coenzyme A binding domain containing 3, D1Ertd10e, DAP, GCP60, GOCAP1, GOLPH1, PAP7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACBD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- protein binding
- Golgi-dynamics membrane-trafficking
- GPCR-chaperone
- ACBP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- head and neck cancer
- esophageal cancer
- renal clear cell cancer
- lung squamous cell carcinoma
- hepatocellular carcinoma
- breast cancer
- renal clear cell adenocarcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
regulated by
- VPR
- OSW-1
- ASPSCR1
role in cell
- expression in
- disassembly
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- cellular membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- Golgi stacks
- brush border membrane vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACBD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty-acyl-CoA binding
- protein kinase A regulatory subunit binding