RPN1 Gene Summary [Human]
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RPN1 |
| Official Name | ribophorin I [Source:HGNC Symbol;Acc:HGNC:10381] |
| Ensembl ID | ENSG00000163902 |
| Bio databases IDs | |
| Aliases | ribophorin I, oligosaccharyltransferase 1 homolog (S. cerevisiae), oligosaccharyltransferase complex subunit (non-catalytic) |
| Synonyms | D6Wsu137e, LOC100363329, OST1, RBPH1, RIBI, Ribophorin, Ribophorin i, RPN-I |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- N-linked glycosylation site
- Ribophorin I
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- endoplasmic reticulum fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondria-associated membranes
- rough endoplasmatic reticulum
- rough endoplasmic reticulum membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- oligosaccharyltransferase complex
- endoplasmic reticulum membrane
- melanosome
- membrane
- rough endoplasmic reticulum
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding
- RNA binding