WT1-AS Gene Summary [Human]
This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | WT1-AS |
| Official Name | WT1 antisense RNA [Source:HGNC Symbol;Acc:HGNC:18135] |
| Ensembl ID | ENSG00000183242 |
| Bio databases IDs | |
| Aliases | WT1 antisense RNA, Wilms tumor associated protein |
| Synonyms | 6030498F17, WIT-1, WT1 antisense, WT1 antisense RNA, WT1-AS1, Wt1os, WT1 transcription factor, opposite strand |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WT1-AS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inguinal hernia
- metabolic syndrome X
- organismal death
- hypertension
- cardiovascular disorder
- pelvic organ prolapse
- non-insulin-dependent diabetes mellitus
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- endometrial carcinoma
regulated by
- PLAG1
- decitabine
regulates
role in cell
- proliferation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WT1-AS gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- protein binding