TRMT12 Gene Summary [Human]
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRMT12 |
| Official Name | tRNA methyltransferase 12 homolog [Source:HGNC Symbol;Acc:HGNC:26091] |
| Ensembl ID | ENSG00000183665 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase 12 homolog, tRNA-yW synthesizing protein 2 |
| Synonyms | 4632406N01Rik, RGD1307127, TRM12, tRNA methyltransferase 12, tRNA methyltransferase 12 homolog, TYW2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRMT12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Met-10+ like-protein
- protein binding
- AdoMet_MTases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRMT12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wybutosine biosynthetic process
- tRNA methylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA methyltransferase activity