ONECUT1
ONECUT1 Gene Summary
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | ONECUT1 |
| Official Name | one cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138] |
| Ensembl ID | ENSG00000169856 |
| Bio databases IDs | |
| Aliases | one cut homeobox 1 |
| Synonyms | D9Ertd423e,Hfh12,HNF-6,HNF6A,Hnf6b,OC-1,one cut domain, family member 1,one cut homeobox 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- LXXLL motif
- nucleic acid binding
- chromatin binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- CUT domain
- serine-rich region
- double-stranded DNA binding
- STP box
- polyhistidine tract
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the ONECUT1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NR1I2
- HMGCR
- IRF3
- HABP2
- FOXA2
- OAZ2
- HSPH1
- WDR5B
- C/EBP
- TRMT12
disease
- hypoplasia
- diabetes mellitus
- insomnia
- growth failure
- jaundice
regulated by
- KAT5
- CREBBP
- GH1
- Pka
- STAT5A
- SOX2/OCT4/NANOG
- Core
- ISX
- FOXA2
- CEBPA
regulates
- triacylglycerol
- CD36
- D-glucose
- luciferase reporter gene
- synthetic promoter
- insulin
- PCK1
- CYP7A1
- Cyp2c12
- HNF4A
role in cell
- differentiation
- expression in
- migration
- quantity
- degeneration
- assembly
- number
- formation
- development
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ONECUT1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cilium morphogenesis
- B cell differentiation
- endoderm development
- transforming growth factor beta receptor signaling pathway
- regulation of transcription, DNA-dependent
- spleen development
- epithelial cell development
- anatomical structure morphogenesis
- glucose metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- pancreatic A cell differentiation
- pancreatic D cell differentiation
- regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- regulation of cell-matrix adhesion
- liver development
- cell fate commitment
- type B pancreatic cell differentiation
- cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- chromatin
MOLECULAR FUNCTION
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity