UBE2O Gene Summary [Human]
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBE2O |
| Official Name | ubiquitin conjugating enzyme E2 O [Source:HGNC Symbol;Acc:HGNC:29554] |
| Ensembl ID | ENSG00000175931 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 O |
| Synonyms | 9630022H21, B230113M03Rik, E2-230K, mKIAA1734, RGD1310297, ubiquitin-conjugating enzyme E2O |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2O often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2O gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- cancer
- metastasis
- advanced cancer
- mumps
- schizophrenia
role in cell
- expression in
- migration
- activation in
- proliferation
- binding in
- growth
- quantity
- generation in
- ubiquitination in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2O gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of BMP signaling pathway
- protein K63-linked ubiquitination
- retrograde transport, endosome to Golgi
- protein monoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- RNA binding
- protein binding