CCT2 Gene Summary [Human]
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | CCT2 |
| Official Name | chaperonin containing TCP1 subunit 2 [Source:HGNC Symbol;Acc:HGNC:1615] |
| Ensembl ID | ENSG00000166226 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 2 |
| Synonyms | 99D8.1, CCTB, CCT-beta, CCT-β, chaperonin containing TCP1 subunit 2, chaperonin containing TCP1, subunit 2 (beta), chaperonin containing TCP1, subunit 2 (β), Chaperonin subunit 2, HEL-S-100n, PRO1633, T-COMPLEX protein 1 beta subunit, T-COMPLEX protein 1 β subunit, TCP-1-beta, TCP-1-β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ubiquitin protein ligase binding
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- albuminuria
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- heart failure
- Leber congenital amaurosis type 1
- amyotrophic lateral sclerosis
- adamantinomatous craniopharyngioma
- head and neck squamous cell cancer
role in cell
- expression in
- degradation in
- growth
- proliferation
- apoptosis
- migration
- invasion by
- processing in
- cell death
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- azurophil granule lumen
- Extracellular Space
- Nucleus
- microtubules
- cytosol
- nucleoli
- perikaryon
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- binding of sperm to zona pellucida
- chaperone mediated protein folding independent of cofactor
- chaperone-mediated protein complex assembly
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- extracellular vesicular exosome
- cell body
- cytosol
- extracellular region
- sperm protein complex
- azurophil granule lumen
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ubiquitin protein ligase binding
- protein binding
- protein binding involved in protein folding
- unfolded protein binding