PSG9 Gene Summary [Human]
The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]
Details
| Type | Retained Intron |
| Official Symbol | PSG9 |
| Official Name | pregnancy specific beta-1-glycoprotein 9 [Source:HGNC Symbol;Acc:HGNC:9526] |
| Ensembl ID | ENSG00000183668 |
| Bio databases IDs | |
| Aliases | pregnancy specific beta-1-glycoprotein 9 |
| Synonyms | pregnancy specific beta-1-glycoprotein 9, pregnancy specific β-1-glycoprotein 9, PS34, PSBG-11, PSBG-9, PSG11, PSGII |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSG9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Immunoglobulin V-set domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSG9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Fc receptor mediated inhibitory signaling pathway
- signal transduction
- transforming growth factor beta receptor signaling pathway
- female pregnancy
- regulation of regulatory T cell differentiation
- negative regulation of cytokine production involved in inflammatory response
- tolerance induction dependent upon immune response
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- transforming growth factor beta1-type II receptor-type I receptor complex
- extracellular region
- plasma membrane
- cell surface