CELSR3
CELSR3 Gene Summary
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | CELSR3 |
| Official Name | cadherin EGF LAG seven-pass G-type receptor 3 [Source:HGNC Symbol;Acc:HGNC:3230] |
| Ensembl ID | ENSG00000008300 |
| Bio databases IDs | |
| Aliases | cadherin EGF LAG seven-pass G-type receptor 3, flamingo homolog 1 (Drosophila), adhesion G protein-coupled receptor C3 |
| Synonyms | ADGRC3,cadherin EGF LAG seven-pass G-type receptor 3,cadherin, EGF LAG seven-pass G-type receptor 3,CDHF11,EGFL1,flamingo,FMI1,HFMI1,MEGF2,mKIAA0812,RESDA1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- LamG
- GPCR-Autoproteolysis INducing (GAIN) domain
- Human growth factor-like EGF
- Keratin, high sulfur B2 protein
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- Cadherin repeat-like domain
- EGF domain
- GPCR proteolysis site, GPS, motif
- laminin G domain
Pathways
Biological processes and signaling networks where the CELSR3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FBXO2
- FYN
- CTNNB1
- PRC1
- SWAP70
- TGOLN2
- PSG9
- SIRT6
- PCDHGB5
- REST
disease
- Crohn disease
- cancer
- respiratory failure
- colorectal cancer
- inflammatory bowel disease
- neuroendocrine prostate cancer
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- cyanosis
- nonsyndromic renal hypodysplasia 1
- atelectasis
regulated by
- PTEN
- TP53
- calcitriol
- GATA2
- CBS
- peripheral blood monocytes
- RB1
- WNT3A
- propylthiouracil
- NCOA1
regulates
- JNK
- dopamine
- FZD3
- NRG1
- FZD8
role in cell
- differentiation
- migration
- quantity
- migration by
- assembly
- patterning
- patterning in
- fasciculation
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- growth cone
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CELSR3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- homophilic cell adhesion
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- calcium ion binding