HGS
HGS Gene Summary
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | HGS |
| Official Name | hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol;Acc:HGNC:4897] |
| Ensembl ID | ENSG00000185359 |
| Bio databases IDs | |
| Aliases | hepatocyte growth factor-regulated tyrosine kinase substrate |
| Synonyms | hepatocyte growth factor-regulated tyrosine kinase substrate,HGF-regulated tyrosine kinase substrate,Hgr,HRS,HRS-1,tn,VPS27,ZFYVE8 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- clathrin binding domain
- phosphatidylinositol-3-phosphate binding domain
- protein binding activity, bridging
- F-type ATP synthase, membrane subunit b
- coiled-coil domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- proline rich domain
- Domain present in VPS-27, Hrs and STAM
- FYVE domain like superfamily
- glycine proline rich domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- ubiquitin binding domain
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- VHS, ENTH and ANTH domain superfamily
- huntingtin binding domain
- GAT_SF
- proline/glutamine rich region
- Ezrin/radixin/moesin, alpha-helical domain
- clathrin box motif
- PSMP motif
- enzyme binding
- protein domain specific binding
- protein binding
- PSAP motif
- CB domain
- P(S/T)XP motif
- PSGP motif
- G-protein pathway suppressor
- PHD finger superfamily
- zinc finger domain
- P(S/T)AP domain
Pathways
Biological processes and signaling networks where the HGS gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PDGFRA
- FGFR2
- RET
- EPHA2
- FGFR1
- NTRK1
- PDGFRB
- DNAJC5
- GJD3
- LAMTOR1
disease
- neoplasia
- epithelial cancer
- liver cancer
- cardiac fibrosis
- cervical cancer
- major depression
- tumorigenesis
- gastric cancer
- skin cancer
- motor dysfunction
regulated by
- lipopolysaccharide
- SYK
- cytokine
- EGF
- CSF2
- PI3K (complex)
- lactacystin
- CD3 (complex)
- dexamethasone
- wortmannin
regulates
- cholesterol
- IL6
- TNF
- IL12B
- CDH1
- KDR
- STAT3
- ERK1/2
- SOX2
- ERBB3
role in cell
- production
- proliferation
- accumulation in
- expression in
- cell death
- growth
- phosphorylation in
- number
- accumulation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- prostasome
- cytoplasmic face of endosomal membrane
- organelle lumens
- membrane surface
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- cytosol
- microdomains
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- cytoplasmic vesicles
- multivesicular bodies
- secretory granules
- cell membrane leading edge
- postsynaptic density
- exosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HGS gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of MAP kinase activity
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- signal transduction
- negative regulation of cell proliferation
- regulation of protein catabolic process
- protein targeting to lysosome
- negative regulation of JAK-STAT cascade
- positive regulation of gene expression
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- endosomal transport
- protein localization in membrane
- membrane invagination
- receptor internalization
- macroautophagy
- endocytic recycling
- negative regulation of platelet-derived growth factor receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- phagocytic vesicle lumen
- extracellular vesicular exosome
- endosome
- ESCRT-0 complex
- cytosol
- multivesicular body membrane
- lysosome
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- ubiquitin binding
- metal ion binding
- phosphatidylinositol binding
- small conjugating protein ligase binding