AGBL4 Gene Summary [Human]
Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in C-terminal protein deglutamylation; defense response to virus; and protein side chain deglutamylation. Predicted to act upstream of or within several processes, including axonal transport of mitochondrion; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of blastocyst development. Located in Golgi apparatus; centriole; and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AGBL4 |
| Official Name | ATP/GTP binding protein like 4 [Source:HGNC Symbol;Acc:HGNC:25892] |
| Ensembl ID | ENSG00000186094 |
| Bio databases IDs | |
| Aliases | ATP/GTP binding protein like 4, AGBL carboxypeptidase 4, cytosolic carboxypeptidase 6 |
| Synonyms | 4930578N11Rik, 4931433A01Rik, AGBL carboxypeptidase 4, ATP/GTP binding protein-like 4, CCP6, Ccp6l1, RGD1559973, RGD1564161 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGBL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- tubulin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- M14 family of metallocarboxypeptidases and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- atrial fibrillation
- esophageal squamous cell cancer
- neuroticism
- major depression
- drug-induced liver disease
- obesity
- insomnia
- methamphetamine dependence
regulates
- alpha tubulin
- tubulin
role in cell
- proliferation
- development
- conversion in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- basal bodies
- Golgi Apparatus
- centriole
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGBL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of cell proliferation
- protein deglutamylation
- proteolysis
- C-terminal protein deglutamylation
- defense response to virus
- central nervous system neuron development
- protein side chain deglutamylation
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- centriole
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- metallocarboxypeptidase activity