BTN3A2 Gene Summary [Human]
This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | BTN3A2 |
| Official Name | butyrophilin subfamily 3 member A2 [Source:HGNC Symbol;Acc:HGNC:1139] |
| Ensembl ID | ENSG00000186470 |
| Bio databases IDs | |
| Aliases | butyrophilin subfamily 3 member A2 |
| Synonyms | BT3.2, BTF4, butyrophilin subfamily 3 member A2, CD277 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTN3A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- major depression
- prostate cancer
- gastroesophageal reflux
- Waldenström macroglobulinemia
- schizophrenia
- pervasive developmental disorder
- neuroticism
- diabetic retinopathy
role in cell
- expression in
- production in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTN3A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell mediated immunity
- positive regulation of interferon-gamma production
- regulation of cytokine production
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding