SLIT1 Gene Summary [Human]
Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLIT1 |
| Official Name | slit guidance ligand 1 [Source:HGNC Symbol;Acc:HGNC:11085] |
| Ensembl ID | ENSG00000187122 |
| Bio databases IDs | |
| Aliases | slit guidance ligand 1 |
| Synonyms | MEGF4, mKIAA0813, SLIL1, SLIT3, slit guidance ligand 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLIT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- LamG
- Human growth factor-like EGF
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- EGF_CA
- leucine-rich repeat
- binding protein
- cytoplasmic domain
- Leucine rich repeat N-terminal domain
- laminin G domain
Pathways
Biological processes and signaling networks where the SLIT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- thyroid carcinoma
- benign monomelic amyotrophy
- epithelial thyroid cancer
- ulcerative colitis
- bipolar disorder
- arthritis
role in cell
- migration
- growth
- formation
- cell death
- guidance
- branching
- development
- calcium oscillation in
- remodeling in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLIT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- retinal ganglion cell axon guidance
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
- motor axon guidance
- nuclear migration
- axon guidance
- negative regulation of axon extension involved in axon guidance
- forebrain morphogenesis
- spinal cord development
- axon extension involved in axon guidance
- dorsal/ventral axon guidance
- negative regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- Roundabout binding
- protein binding
- calcium ion binding
- heparan sulfate proteoglycan binding
- heparin binding