SSTR2 Gene Summary [Human]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SSTR2 |
| Official Name | somatostatin receptor 2 [Source:HGNC Symbol;Acc:HGNC:11331] |
| Ensembl ID | ENSG00000180616 |
| Bio databases IDs | |
| Aliases | somatostatin receptor 2 |
| Synonyms | Smstr-2, somatostatin receptor 2, SRIF-1, SS2R, SST2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSTR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- somatostatin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
- protein heterodimerization
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the SSTR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- neoplasia
- carcinoma
- cervical cancer
- prostate cancer
- acromegaly
- coronary artery disease
- neuroendocrine gastroenteropancreatic tumor
- well-differentiated pancreatic neuroendocrine tumor
- bronchial neuroendocrine tumor
role in cell
- proliferation
- activation in
- cell viability
- apoptosis
- phosphorylation in
- expression in
- production in
- G1 phase
- migration
- internalization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSTR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- cellular response to estradiol stimulus
- forebrain development
- cerebellum development
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- cellular response to glucocorticoid stimulus
- spermatogenesis
- negative regulation of cell proliferation
- response to starvation
- peristalsis
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- PDZ domain binding
- somatostatin receptor activity