SERPINA5 Gene Summary [Human]
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | SERPINA5 |
| Official Name | serpin family A member 5 [Source:HGNC Symbol;Acc:HGNC:8723] |
| Ensembl ID | ENSG00000188488 |
| Bio databases IDs | |
| Aliases | serpin family A member 5, Protein C inhibitor |
| Synonyms | PAI-3, PCI, PCI-B, PLANH3, PLASMA SERINE PROTEASE INHIBITOR, PROCI, serpin family A member 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- heparin binding domain
- enzyme binding
- retinoid binding
- protein binding
- Serpin (serine protease inhibitor)
- glycosaminoglycan binding
- reactive serpin loop
- binding protein
- heparin binding
Pathways
Biological processes and signaling networks where the SERPINA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- thrombosis
- breast carcinoma
- necrotizing fasciitis
- Klinefelter syndrome
role in cell
- killing
- replication in
- binding
- motility
- migration
- permeabilization
- disruption
- contact growth inhibition
- disruption in
- efflux
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- cell surface
- intracellular space
- cellular membrane
- Plasma Membrane
- plasma membrane extracellular face
- alpha granules
- acrosome
- exosomes
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- negative regulation of hydrolase activity
- spermatogenesis
- negative regulation of endopeptidase activity
- fusion of sperm to egg plasma membrane
Cellular Component
Where in the cell the gene product is active
- protein C inhibitor-TMPRSS7 complex
- platelet dense tubular network
- platelet alpha granule
- protein C inhibitor-TMPRSS11E complex
- protein C inhibitor-PLAT complex
- protein C inhibitor-plasma kallikrein complex
- acrosomal membrane
- external side of plasma membrane
- protein C inhibitor-coagulation factor Xa complex
- protein C inhibitor-coagulation factor V complex
- extracellular region
- protein C inhibitor-coagulation factor XI complex
- extracellular space
- extracellular vesicular exosome
- membrane
- macromolecular complex
- protein C inhibitor-PLAU complex
- protein C inhibitor-thrombin complex
- protein C inhibitor-KLK3 complex
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- serine-type endopeptidase inhibitor activity
- protein binding
- glycosaminoglycan binding
- heparin binding
- protease binding
- phosphatidylcholine binding
- acrosin binding