HECTD3 Gene Summary [Human]
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
Details
| Type | Processed Transcript |
| Official Symbol | HECTD3 |
| Official Name | HECT domain E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:26117] |
| Ensembl ID | ENSG00000126107 |
| Bio databases IDs | |
| Aliases | HECT domain E3 ubiquitin protein ligase 3 |
| Synonyms | 1700064K09RIK, AI467540, HECT domain E3 ubiquitin protein ligase 3, RGD1309823 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HECTD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- APC10-like
- F5/8 type C domain
- enzyme
- protein binding
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonitis
- acute myeloid leukemia
- gouty arthritis
- hepatitis
- infection by bacteria
role in cell
- phosphorylation in
- production in
- activation in
- replication in
- ubiquitination in
- binding in
- assembly in
- oligomerization in
- dimerization in
- K33 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HECTD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- syntaxin binding