INPPL1 Gene Summary [Human]
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | INPPL1 |
| Official Name | inositol polyphosphate phosphatase like 1 [Source:HGNC Symbol;Acc:HGNC:6080] |
| Ensembl ID | ENSG00000165458 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate phosphatase like 1, 51C protein, SH2 domain-containing inositol 5'-phosphatase 2, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
| Synonyms | 51C, inositol polyphosphate phosphatase-like 1, OPSMD, SHIP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INPPL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 5' phosphatase domain
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- catalytic domain
- SH2-domain binding
- SAM (Sterile alpha motif )
- SAM domain
- inositol-polyphosphate 5-phosphatase
- protein binding
- phosphotyrosine binding domain
- phosphatase domain
- proline rich domain
- phosphorylation site
- Sterile alpha motif
- phosphatidylinositol-3,4,5-triphosphate binding
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- SAM domain (Sterile alpha motif)
- phosphatase
- Src homology 2 (SH2) domain
- PR domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the INPPL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- opsismodysplasia
- obesity
- chronic lymphocytic leukemia
- liver cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- weight gain
role in cell
- apoptosis
- migration
- proliferation
- phosphorylation in
- quantity
- assembly
- cell spreading
- distribution
- capivasertib resistance
- endochondral ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- focal complexes
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- basal membrane
- spindle pole
- nuclear speckles
- sarcolemma
- Z line
- cellular protrusions
- cell membrane leading edge
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INPPL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- post-embryonic development
- actin filament organization
- cell adhesion
- phosphatidylinositol biosynthetic process
- glucose metabolic process
- endocytosis
- immune system process
- negative regulation of insulin-like growth factor receptor signaling pathway
- phosphatidylinositol dephosphorylation
- ERK1 and ERK2 cascade
- negative regulation of gene expression
- protein kinase B signaling cascade
- response to insulin stimulus
- ruffle assembly
- apoptotic process
- endochondral ossification
- gene expression
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- basal plasma membrane
- nuclear speck
- spindle pole
- cytosol
- filopodium
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- SH3 domain binding
- SH2 domain binding
- inositol-polyphosphate 5-phosphatase activity