NDOR1 Gene Summary [Human]
This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Details
| Type | Retained Intron |
| Official Symbol | NDOR1 |
| Official Name | NADPH dependent diflavin oxidoreductase 1 [Source:HGNC Symbol;Acc:HGNC:29838] |
| Ensembl ID | ENSG00000188566 |
| Bio databases IDs | |
| Aliases | NADPH dependent diflavin oxidoreductase 1, NADPH dependent FMN and FAD containing oxidoreductase |
| Synonyms | 4930447P04Rik, AL732309.1, AL732309.2, bA350O14.9, CIAE1, LOC648245, NADPH dependent diflavin oxidoreductase 1, Ndor, NR1, Tg(UBC-cre/ERT2)1Ejb, Ubc-cre |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDOR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- electron carrier
- FAD binding domain
- NADH or NADPH:heme protein oxidoreductase
- flavodoxin
- enzyme
- protein binding
- NADPH-dependent FMN reductase
- iron-sulfur protein:NAD or NADP oxidoreductase
- FAD binding
- NADPH binding
- NADP binding
- FMN binding
- sulfite reductase [NADPH] flavoprotein, alpha-component
- Oxidoreductase NAD-binding domain
- NADPH-ferrihemoprotein reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDOR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- electron transport chain
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- NADP binding
- protein binding
- FMN binding
- oxidoreductase activity
- flavin adenine dinucleotide binding
- electron carrier activity
- NADPH-hemoprotein reductase activity
- NADPH binding
- oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
- oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor