IL36G Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]
Details
| Type | Protein Coding |
| Official Symbol | IL36G |
| Official Name | interleukin 36 gamma [Source:HGNC Symbol;Acc:HGNC:15741] |
| Ensembl ID | ENSG00000136688 |
| Bio databases IDs | |
| Aliases | interleukin 36 gamma, interleukin-1 homolog 1, interleukin 1-related protein 2, interleukin-1 epsilon |
| Synonyms | If36g, IL1E, IL-1F9, IL-1H1, IL-1RP2, IL-36gamma, interleukin 36G, interleukin 36 gamma, interleukin 36, gamma, interleukin 36 γ, interleukin 36, γ, RGD1563019 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL36G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL36G gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- acne
- paralysis
- inflammatory bowel disease
- congenital erythroderma with palmoplantar keratoderma, hypotrichosis, and hyper-IgE
- pruritus
- psoriasis
- contact hypersensitivity
- psoriatic lesion
- colitis
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- survival
- killing
- autophagy in
- activation
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL36G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- inflammatory response to antigenic stimulus
- innate immune response
- positive regulation of gene expression
- cytokine-mediated signaling pathway
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cytokine activity
- interleukin-1 receptor binding