GNB4
GNB4 Gene Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GNB4 |
| Official Name | G protein subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:20731] |
| Ensembl ID | ENSG00000114450 |
| Bio databases IDs | |
| Aliases | G protein subunit beta 4, transducin beta chain 4, Guanine nucleotide-binding protein subunit beta-4 |
| Synonyms | 6720453A21RIK,CMTD1F,Gb4,GBB4,G(beta)4,G protein beta 4,G protein subunit beta 4,G protein subunit β 4,G protein β 4,guanine nucleotide binding protein (G protein), beta 4,guanine nucleotide binding protein (G protein), β 4,G(β)4,HG2B,LOC103691541,LOC107986157 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- GTPase
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the GNB4 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Protein Kinase A Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDC123
- ESR1
- PRKN
- CEP97
- PRKAR1B
- GALK2
- YWHAG
- USP7
- GNG5
- KIF20A
disease
- neoplasia
- adenoma formation
- Charcot-Marie-Tooth disease dominant intermediate type F
- gastric cancer
- organismal death
- metastasis
- Charcot-Marie-Tooth disease
- Alzheimer disease
- atrial fibrillation
- pituitary gland adenoma
regulated by
- NLRX1
- IFNB1
- TGFB1
- BMP6
- CSF3
- LGR6
- IL4
- ALK
- EGR2
- TNF
regulates
- Ca2+
- N-type calcium channel
- PLCB1
- PLCE1
- PLCB2
- PLC beta
- CACNA1B
- GNAS
- ADCY1
- ADCY2
role in cell
- proliferation
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cytosol
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNB4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- substantia nigra development
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- heterotrimeric G-protein complex
- cytoplasm
- cell body
- cytosol
- lysosomal membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- receptor signaling complex scaffold activity