IDO2
IDO2 Gene Summary
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Details
| Type | Processed Transcript |
| Official Symbol | IDO2 |
| Official Name | indoleamine 2,3-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:27269] |
| Ensembl ID | ENSG00000188676 |
| Bio databases IDs | |
| Aliases | indoleamine 2,3-dioxygenase 2 |
| Synonyms | C230043N17Rik,INDOL1,indoleamine 2,3-dioxygenase 2,LOC684861 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- indoleamine 2,3-dioxygenase
Pathways
Biological processes and signaling networks where the IDO2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RANBP10
- RUNX1
- DPP8
- GAPDH
- HLA-A
- EME1
- ATF1
- NRN1
- KLF12
- SMARCA1
disease
- hepatocellular carcinoma
- breast cancer
- liver cancer
- epithelial cancer
- diabetic nephropathy
- delayed hypersensitive reaction
- contact hypersensitivity
- allergic contact dermatitis
- necrotizing enterocolitis
regulated by
- CD40LG
- IFNG
- IDO
- benzo(a)pyrene
- lipopolysaccharide
- 6-formylindolo[3,2-b]carbazole
- IFN beta
- AHR
- tetrachlorodibenzodioxin
- ISX
regulates
- IFNG
- TNF
- IL6
- L-tryptophan
- chemokine
- CD40
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IDO2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- de novo NAD biosynthetic process from tryptophan
- tryptophan catabolic process to kynurenine
- immune system process
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- tryptophan 2,3-dioxygenase activity
- metal ion binding
- heme binding
- indoleamine 2,3-dioxygenase activity