KLF12 Gene Summary [Human]
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KLF12 |
| Official Name | Kruppel like factor 12 [Source:HGNC Symbol;Acc:HGNC:6346] |
| Ensembl ID | ENSG00000118922 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 12, KLF transcription factor 12, KLF12 zinc finger transcriptional repressor, AP-2rep transcription factor, AP-2 repressor |
| Synonyms | 2700063E05RIK, AP2REP, B130052C06RIK, D530033K05RIK, HSPC122, KLF transcription factor 12, Kruppel-like transcription factor 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- CtBP binding domain
- transcription regulator
- N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- prostate cancer
- major depression
- pulmonary emphysema
- atrial fibrillation
- bronchopulmonary dysplasia
- human papilloma virus infection
- alcoholism
- systemic lupus erythematosus
role in cell
- expression in
- apoptosis
- binding in
- differentiation
- proliferation
- S phase
- growth
- transactivation in
- development
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity