KCTD21 Gene Summary [Human]
Enables cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KCTD21 |
| Official Name | potassium channel tetramerization domain containing 21 [Source:HGNC Symbol;Acc:HGNC:27452] |
| Ensembl ID | ENSG00000188997 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerization domain containing 21 |
| Synonyms | EG622320, KCASH2, potassium channel tetramerisation domain containing 21, potassium channel tetramerization domain containing 21, RGD1559529 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCTD21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB/POZ domain-containing protein KCTD11/21 C-terminus
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- histone deacetylase binding
- protein binding
- identical protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCTD21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- negative regulation of smoothened signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- histone deacetylase binding