RNF25 Gene Summary [Human]
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | RNF25 |
| Official Name | ring finger protein 25 [Source:HGNC Symbol;Acc:HGNC:14662] |
| Ensembl ID | ENSG00000163481 |
| Bio databases IDs | |
| Aliases | ring finger protein 25 |
| Synonyms | 0610009H16Rik, AO7, ring finger protein 25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RWD, DRWD, and ELF domain family
- NF-kappaB binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RWD domain
- Ring finger domain
- protein binding
- RING-like zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- positive regulation of NF-kappaB transcription factor activity
- protein K6-linked ubiquitination
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding