AMZ2 Gene Summary [Human]
The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | AMZ2 |
| Official Name | archaelysin family metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:28041] |
| Ensembl ID | ENSG00000196704 |
| Bio databases IDs | |
| Aliases | archaelysin family metallopeptidase 2, archaemetzincin-2 |
| Synonyms | AA408420, archaelysin family metallopeptidase 2, ESTM12, RGD1304846 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMZ2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZnMc
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMZ2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metallopeptidase activity