ARRDC1 Gene Summary [Human]
Enables several functions, including arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | ARRDC1 |
| Official Name | arrestin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28633] |
| Ensembl ID | ENSG00000197070 |
| Bio databases IDs | |
| Aliases | arrestin domain containing 1, alpha-arrestin 1 |
| Synonyms | AI957342, arrestin domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARRDC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Arrestin (or S-antigen), C-terminal domain
- protein binding activity, bridging
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- Plasma Membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARRDC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular transport
- protein transport
- negative regulation of Notch signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding