OSBPL6 Gene Summary [Human]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | OSBPL6 |
| Official Name | oxysterol binding protein like 6 [Source:HGNC Symbol;Acc:HGNC:16388] |
| Ensembl ID | ENSG00000079156 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein like 6, OSBP-related protein 6 |
| Synonyms | 1110062M20RIK, mKIAA4128, ORP-6, oxysterol binding protein-like 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OSBPL6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- endosomal membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OSBPL6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- regulation of cholesterol transport
- bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- nuclear membrane
- perinuclear endoplasmic reticulum
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding