Arrdc1 Gene Summary [Mouse]
Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; nasal cavity epithelium; and respiratory system. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arrdc1 |
| Official Name | arrestin domain containing 1 [Source:MGI Symbol;Acc:MGI:2446136] |
| Ensembl ID | ENSMUSG00000026972 |
| Bio databases IDs | |
| Aliases | arrestin domain containing 1 |
| Synonyms | AI957342, arrestin domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arrdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Arrestin (or S-antigen), C-terminal domain
- protein binding activity, bridging
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- Plasma Membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arrdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular transport
- protein transport
- negative regulation of Notch signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding