ZBTB14
ZBTB14 Gene Summary
Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB14 |
| Official Name | zinc finger and BTB domain containing 14 [Source:HGNC Symbol;Acc:HGNC:12860] |
| Ensembl ID | ENSG00000198081 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 14 |
| Synonyms | b2b1982Clo,ZF5,ZFP-161,ZFP-5,zinc finger and BTB domain containing 14,ZNF478 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- BTB_POZ
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the ZBTB14 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RNPS1
- PRPF40A
- RAN
- RPL9
- RPA2
- PSME3
- NAA10
- CAPN6
- MAD2L1BP
- ATP5PO
disease
- congenital heart disease
regulated by
- TGFB1
- SIRT1
regulates
- MYC
- DNA endogenous promoter
- RNA polymerase II
- DNA promoter
- SP1
- Rep78
role in cell
- camptothecin resistance
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ZBTB14 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- heart valve development
- kidney development
- coronary vasculature development
- regulation of transcription from RNA polymerase II promoter
- cardiac septum development
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- aggresome
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription