PSME3 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Details
| Type | Processed Transcript |
| Official Symbol | PSME3 |
| Official Name | proteasome activator subunit 3 [Source:HGNC Symbol;Acc:HGNC:9570] |
| Ensembl ID | ENSG00000131467 |
| Bio databases IDs | |
| Aliases | proteasome activator subunit 3 |
| Synonyms | AA410043, Ab2-371, HEL-S-283, Ki, Ki Nuclear Autoantigen, PA28G, PA28-gamma, PA28-γ, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki), proteaseome (prosome, macropain) activator subunit 3 (PA28 γ, Ki), proteasome activator subunit 3, Proteasome (prosome, macropain) activator subunit 3 (pa28 γ), REG-GAMMA, REG-γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSME3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- p53 binding
- protein binding
- enzyme regulator activity
- protease activator
- Proteasome activator pa28 beta subunit
- identical protein binding
- Proteasome activator pa28 alpha subunit
Pathways
Biological processes and signaling networks where the PSME3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- tumorigenesis
- hepatic steatosis
- Waldenström macroglobulinemia
- growth failure
- premature aging
- liver neoplasia
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- differentiation
- formation
- cell viability
- accumulation in
- number
- cell saturation density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- basal bodies
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSME3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- proteasome complex
- proteasome activator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- identical protein binding
- p53 binding
- protein binding