TCAF1 Gene Summary [Human]
Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TCAF1 |
| Official Name | TRPM8 channel associated factor 1 [Source:HGNC Symbol;Acc:HGNC:22201] |
| Ensembl ID | ENSG00000198420 |
| Bio databases IDs | |
| Aliases | TRPM8 channel associated factor 1 |
| Synonyms | 2810407D09RIK, 3321401G04Rik, A230020K05RIK, FAM115A, GATD9A, RGD1565474, TRPM8 channel-associated factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal domain of M60-like peptidases
- Peptidase M60, enhancin and enhancin-like
- ion channel binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding