ZNF143 Gene Summary [Human]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF143 |
| Official Name | zinc finger protein 143 [Source:HGNC Symbol;Acc:HGNC:12928] |
| Ensembl ID | ENSG00000166478 |
| Bio databases IDs | |
| Aliases | zinc finger protein 143 |
| Synonyms | D7Ertd805e, KRAB14, pHZ-1, SBF, STAF, Zfp143, Zfp79, Zfp80-rs1, zinc finger protein 143 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF143 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- chromatin binding
- zinc finger domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- organismal death
- hepatocellular carcinoma
- liver cancer
- methylmalonic acidemia with homocystinuria
role in cell
- expression in
- proliferation
- quantity
- transactivation in
- colony formation by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF143 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity