TRPM8 Gene Summary [Human]
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRPM8 |
| Official Name | transient receptor potential cation channel subfamily M member 8 [Source:HGNC Symbol;Acc:HGNC:17961] |
| Ensembl ID | ENSG00000144481 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily M member 8 |
| Synonyms | CMR1, LTRPC6, transient receptor potential cation channel subfamily M member 8, transient receptor potential cation channel, subfamily M, member 8, TRPP8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRPM8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- transmembrane helix kinks
- SLOG in TRPM
- calcium channel
- N-terminal tail
- tail domain
- protein binding
- identical protein binding
- ion channel
Pathways
Biological processes and signaling networks where the TRPM8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dry eye
- prostate cancer
- cold allodynia
- adult-onset obesity
- Crohn disease
- benign prostatic hyperplasia
- cold pain
- asthma
- cerebral aneurysm
- hypothermia
role in cell
- expression in
- adhesion
- survival
- migration
- motility
- formation by
- signaling in
- homeostasis in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- perinuclear membrane
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRPM8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- calcium ion transmembrane transport
- thermoception
- calcium-mediated signaling
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane raft
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium channel activity