MIR126 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR126 |
| Official Name | microRNA 126 [Source:HGNC Symbol;Acc:HGNC:31508] |
| Ensembl ID | ENSG00000199161 |
| Bio databases IDs | |
| Aliases | microRNA 126 |
| Synonyms | HSA-MIR-123, hsa-miR-126, MI0000149, microRNA 123, microRNA 126, microRNA 126a, microRNA 126b, miR-123, Mir126a, Mir126b, Mir3567, MIRN123, MIRN126, miRNA126, mmu-mir-123, mmu-mir-126, mmu-mir-126a, mmu miR 126 AS, mmu-mir-126b, rno-miR-126, rno-mir-126a, rno-mir-126b, rno-mir-3567 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR126 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR126 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck squamous cell cancer
- epithelial cancer
- head and neck cancer
- squamous cell cancer
- head and neck neoplasia
- epithelial neoplasia
- cancer
- non-insulin-dependent diabetes mellitus
- atherosclerosis
role in cell
- expression in
- apoptosis
- activation in
- proliferation
- growth
- migration
- quiescence
- expansion
- differentiation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR126 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- negative regulation of proteolysis
- positive regulation of MAPK cascade
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of Notch signaling pathway
- positive regulation of angiogenesis
- positive regulation of blood vessel endothelial cell migration
- positive regulation of ERK1 and ERK2 cascade
- cellular response to laminar fluid shear stress
- negative regulation of endothelial cell apoptotic process
- cellular response to hypoxia
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding