PLK2 Gene Summary [Human]
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | PLK2 |
| Official Name | polo like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19699] |
| Ensembl ID | ENSG00000145632 |
| Bio databases IDs | |
| Aliases | polo like kinase 2, serum-inducible kinase |
| Synonyms | hPlk2, hSNK, POLO-LIKE KINASE 2, Serum Inducible Kinase, SNK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- POLO box duplicated region
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- clathrin binding
- protein binding
- Protein kinase domain
- POLO_box
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- ATPase binding
- binding protein
- Protein Kinases, catalytic domain
- ATP-dependent protein binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PLK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- biliary tract cancer
- epithelial cancer
- epithelial neoplasia
- alveolar rhabdomyosarcoma
- soft tissue sarcoma cancer
- liver cancer
- Alzheimer disease
- endometriosis
- Huntington disease
role in cell
- growth
- apoptosis
- expression in
- cell cycle progression
- organization
- survival
- S phase
- G1/S phase transition
- autophagy by
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- postsynaptic region
- cellular membrane
- centrosome
- centriole
- cytosol
- nucleoplasm
- dendritic spines
- chromatin
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- mitotic spindle organization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of protein catabolic process
- Ras protein signal transduction
- regulation of centriole replication
- positive regulation of cell migration involved in sprouting angiogenesis
- protein phosphorylation
- memory
- negative regulation of inflammatory response to antigenic stimulus
- positive regulation of autophagy
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of apoptotic process
- G1/S transition of mitotic cell cycle
- regulation of synaptic plasticity
- long-term synaptic potentiation
- Rap protein signal transduction
- long term synaptic depression
- peptidyl-serine phosphorylation
- negative regulation of apoptotic process in bone marrow
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- centrosome
- centriole
- cytoplasm
- spindle pole
- cytosol
- kinetochore
- chromatin
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- ATP-dependent protein binding