ETS2 Gene Summary [Human]
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | ETS2 |
| Official Name | ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489] |
| Ensembl ID | ENSG00000157557 |
| Bio databases IDs | |
| Aliases | ETS proto-oncogene 2, transcription factor |
| Synonyms | E26 avian leukaemia oncogene 2, 3' domain, E26 avian leukemia oncogene 2, 3' domain, ETS2IT1, ETS proto-oncogene 2, transcription factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ETS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- autoinhibitory protein domain
- DNA binding domain
- nucleic acid binding
- SAM (Sterile alpha motif )
- transcription activation domain
- transcription factor binding
- inhibitory domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- ETS interacting domain
- Ets-domain
- pointed domain
- ERK phosphorylation site
Pathways
Biological processes and signaling networks where the ETS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- prostate cancer
- Alzheimer disease
- HER2 negative hormone receptor negative breast cancer
- Down syndrome
- lung adenocarcinoma
role in cell
- expression in
- apoptosis
- proliferation
- quantity
- cell death
- growth
- phosphorylation in
- binding in
- activation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ETS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal system development
- ectodermal cell fate commitment
- cell differentiation
- mesoderm development
- positive regulation of transcription from RNA polymerase II promoter
- primitive streak formation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein domain specific binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- glucocorticoid receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity