PIK3R2
PIK3R2 Gene Summary
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]
Details
| Type | Protein Coding |
| Official Symbol | PIK3R2 |
| Official Name | phosphoinositide-3-kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:8980] |
| Ensembl ID | ENSG00000105647 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase regulatory subunit 2, phosphoinositide-3-kinase regulatory subunit beta |
| Synonyms | MPPH,MPPH1,p85,P85B,p85-BETA,P85 β,phosphoinositide-3-kinase regulatory subunit 2,PI3K p85beta,PI3K p85β,Pi3kr2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- protein phosphatase binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- phosphotyrosine binding
- protein binding
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- proline rich domain
- Src Homology 3 domain superfamily
- inter-SH2 domain
- kinase
- phosphoinositide 3-kinase binding
- receptor tyrosine kinase binding
- Src homology 2 (SH2) domain
- iSH2_PI3K_IA_R
- protein heterodimerization
Pathways
Biological processes and signaling networks where the PIK3R2 gene plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FGFR1
- PIK3R1
- PIK3CA
- EBF1
- NS1
- CBL
- DPP4
- ABI1
- MBP
- STAT3
disease
- endometriosis
- epithelial cancer
- hereditary disorder
- insulin resistance
- mental retardation
- megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome type 1
- survival
- colon neoplasm
- colorectal neoplasia
- neoplastic cell transformation
regulated by
- IL3
- AGT
- beta-estradiol
- ERBB2
- CDC42
- SPP1
- insulin
- HCK
- Influenza A virus
- CSF1
regulates
- LH
- Ca2+
- AKT
- RPS6KB1
- BCL2L1
- PLAU
- EIF4E
- ERK
- IL12 (family)
- IFNG
role in cell
- expression in
- apoptosis
- phosphorylation in
- signaling in
- growth
- activation in
- survival
- cell cycle progression
- proliferation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- focal adhesions
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIK3R2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- B cell differentiation
- insulin receptor signaling pathway
- negative regulation of MAPK cascade
- protein transport
- regulation of stress fiber assembly
- phosphatidylinositol phosphorylation
- positive regulation of cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- T cell differentiation
- regulation of actin filament polymerization
- cellular response to insulin stimulus
- protein kinase B signaling cascade
- immune response
- cellular glucose homeostasis
- regulation of autophagy
- response to endoplasmic reticulum stress
CELLULAR COMPONENT
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- nucleus
- phosphatidylinositol 3-kinase complex
- focal adhesion
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- protein phosphatase binding
- protein heterodimerization activity
- 1-phosphatidylinositol-3-kinase regulator activity
- receptor tyrosine kinase binding