TECPR1 Gene Summary [Human]
This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | TECPR1 |
| Official Name | tectonin beta-propeller repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:22214] |
| Ensembl ID | ENSG00000205356 |
| Bio databases IDs | |
| Aliases | tectonin beta-propeller repeat containing 1 |
| Synonyms | 2210010N04Rik, mKIAA1358, RGD1306873, tectonin beta-propeller repeat containing 1, tectonin β-propeller repeat containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TECPR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- Dysferlin domain, N-terminal region
- TECPR
- Tectonin domain
- PH domain
- Dysferlin domain, C-terminal region
- protein binding
- Pleckstrin homology-like domain
- Propeller
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- Moyamoya disease
regulated by
role in cell
- accumulation in
- fusion
- degradation in
- maturation
- autophagy
- accumulation
- autophagy by
- autophagy in
- maturation in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome membrane
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TECPR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- macromolecular complex
- autophagic vacuole membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3-phosphate binding