Tecpr1 Gene Summary [Rat]
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation and regulation of autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tecpr1 |
| Official Name | tectonin beta-propeller repeat containing 1 [Source:RGD Symbol;Acc:1306873] |
| Ensembl ID | ENSRNOG00000001010 |
| Bio databases IDs | |
| Aliases | tectonin beta-propeller repeat containing 1 |
| Synonyms | 2210010N04Rik, mKIAA1358, RGD1306873, tectonin beta-propeller repeat containing 1, tectonin β-propeller repeat containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tecpr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- Dysferlin domain, N-terminal region
- TECPR
- Tectonin domain
- PH domain
- Dysferlin domain, C-terminal region
- protein binding
- Pleckstrin homology-like domain
- Propeller
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- Moyamoya disease
regulated by
role in cell
- accumulation in
- fusion
- degradation in
- maturation
- autophagy
- accumulation
- autophagy by
- autophagy in
- maturation in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome membrane
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tecpr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- macromolecular complex
- autophagic vacuole membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3-phosphate binding