IGHV4-28 Gene Summary [Human]
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Variable Gene |
| Official Symbol | IGHV4-28 |
| Official Name | immunoglobulin heavy variable 4-28 [Source:HGNC Symbol;Acc:HGNC:5645] |
| Ensembl ID | ENSG00000211952 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy variable 4-28 |
| Synonyms | immunoglobulin heavy variable 4-28, VH |
| Species | Human, Homo sapiens |
Pathways
Biological processes and signaling networks where the IGHV4-28 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- limited systemic sclerosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGHV4-28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immunoglobulin mediated immune response
Cellular Component
Where in the cell the gene product is active
- immunoglobulin complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- antigen binding