icon_0328_cc_gen_hmr_bacteria-s

IL-15 Signaling

Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 signaling is mainly mediated via a transmembrane heterotrimeric receptor complex that consists of a high affinity ligand binding subunit IL-15Rα and -β and -γ signal transducing subunits. The latter two it shares with IL-2. IL-15 can also signal via an intermediate affinity receptor...

IL-15 Signaling

Pathway Summary

Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 signaling is mainly mediated via a transmembrane heterotrimeric receptor complex that consists of a high affinity ligand binding subunit IL-15Rα and -β and -γ signal transducing subunits. The latter two it shares with IL-2. IL-15 can also signal via an intermediate affinity receptor. Mast cells use a unique receptor, IL-15RX, to mediate signal transduction. IL-15 activates various signaling pathways in different cell types including the JAK/STAT, MAPK and NF-κB pathways to control cell growth and differentiation, enhance phagocytosis and increase the inflammatory response.IL-15 uses juxtacrine and reverse signaling mechanisms in certain cell types, since its major form is membrane-bound, not soluble. For example, reverse signaling occurs in monocytes when the membrane-bound IL-15 is stimulated with soluble IL-15Rα or anti-IL-15 Abs, which can result in activation of ERK, p38MAPK or FAK pathways. In juxtacrine signaling, monocyte membrane-bound IL-15 binds to the receptor complex on neighboring T-cells and initiates signal transduction. (Upgraded 01/2020)

IL-15 Signaling Genes list

Explore Genes related to IL-15 Signaling

Products related to IL-15 Signaling

Explore products related to IL-15 Signaling
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-021Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Common Cytokines
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-021Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Common Cytokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-021Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Common Cytokines
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.