Communication between Innate and Adaptive Immune Cells
The immune response to an infection can be divided into the innate and adaptive phases that act in synergy to eliminate pathogens. Activation of the innate immune system following antigen detection results in rapid elimination of pathogen and prevention of infection. In contrast, the adaptive immune response develops after a time lag, but results in the activation of cells that are highly specific and effective in eliminating the pathogen. The quality and magnitude of the adaptive immune response is dependent on the innate immune response.Cells involved in the innate immune response include natural killer (NK) cells, natural interferon producing cells (NIPC), dendritic cells and macrophages...
Pathway Summary
The immune response to an infection can be divided into the innate and adaptive phases that act in synergy to eliminate pathogens. Activation of the innate immune system following antigen detection results in rapid elimination of pathogen and prevention of infection. In contrast, the adaptive immune response develops after a time lag, but results in the activation of cells that are highly specific and effective in eliminating the pathogen. The quality and magnitude of the adaptive immune response is dependent on the innate immune response.Cells involved in the innate immune response include natural killer (NK) cells, natural interferon producing cells (NIPC), dendritic cells and macrophages. Many innate immune cells possess pattern recognition receptors (PRRs) such as toll-like receptors (TLR) that detect molecular signatures in pathogens resulting in antigen recognition and presentation. After recognition of antigen, cells of the innate immune system reciprocally activate one another as well as cells of the adaptive immune system like the T and B lymphocytes.Dendritic cells are considered to be the link between the innate and adaptive immune responses. In their immature state, DCs are good detectors of antigen, but poor presenters of antigen to T cells and B cells. However, after detection of antigen via TLRs, DCs mature into efficient antigen presenting cells secreting several cytokines such as type I interferons, IL-12, IL-15 and chemokines such as IL-8 and macrophage inflammatory protein 1 (MIP1). These soluble mediators as well as cell-cell interactions result in the activation of T and B lymphocytes and thus the development of cellular and humoral adaptive immune responses.This pathway highlights the different modes of cross talk between the innate and adaptive immune systems namely via soluble factors (chemokines and cytokines) and cell-to-cell communication.
Communication between Innate and Adaptive Immune Cells Genes list
Explore Genes related to Communication between Innate and Adaptive Immune Cells
B2Mbeta-2-microglobulin CCL15C-C motif chemokine ligand 15 CCL3C-C motif chemokine ligand 3 CCL3L3C-C motif chemokine ligand 3 like 3 CCL4C-C motif chemokine ligand 4 CCL5C-C motif chemokine ligand 5 CCR7C-C motif chemokine receptor 7 CD28CD28 molecule CD4CD4 molecule CD40CD40 molecule CD40LGCD40 ligand CD79ACD79a molecule CD79BCD79b molecule CD80CD80 molecule CD83CD83 molecule CD86CD86 molecule CSF2colony stimulating factor 2 CXCL10C-X-C motif chemokine ligand 10 CXCL8C-X-C motif chemokine ligand 8 HLA-Amajor histocompatibility complex, class I, A HLA-Bmajor histocompatibility complex, class I, B HLA-Cmajor histocompatibility complex, class I, C HLA-DRAmajor histocompatibility complex, class II, DR alpha HLA-DRB1major histocompatibility complex, class II, DR beta 1 HLA-DRB3major histocompatibility complex, class II, DR beta 3 HLA-DRB4major histocompatibility complex, class II, DR beta 4 HLA-DRB5major histocompatibility complex, class II, DR beta 5 HLA-Emajor histocompatibility complex, class I, E HLA-Fmajor histocompatibility complex, class I, F HLA-Gmajor histocompatibility complex, class I, G IFNA21interferon alpha 21 IFNA5interferon alpha 5 IFNB1interferon beta 1 IFNGinterferon gamma IGHA1immunoglobulin heavy constant alpha 1 IGHA2immunoglobulin heavy constant alpha 2 (A2m marker) IGHDimmunoglobulin heavy constant delta IGHD1-1immunoglobulin heavy diversity 1-1 IGHD1-14immunoglobulin heavy diversity 1-14 (non-functional) IGHD1-20immunoglobulin heavy diversity 1-20 IGHD1-26immunoglobulin heavy diversity 1-26 IGHD1-7immunoglobulin heavy diversity 1-7 IGHD2-15immunoglobulin heavy diversity 2-15 IGHD2-2immunoglobulin heavy diversity 2-2 IGHD2-21immunoglobulin heavy diversity 2-21 IGHD2-8immunoglobulin heavy diversity 2-8 IGHD3-10immunoglobulin heavy diversity 3-10 IGHD3-16immunoglobulin heavy diversity 3-16 IGHD3-22immunoglobulin heavy diversity 3-22 IGHD3-3immunoglobulin heavy diversity 3-3 IGHD3-9immunoglobulin heavy diversity 3-9 IGHD4-11immunoglobulin heavy diversity 4-11 (non-functional) IGHD4-17immunoglobulin heavy diversity 4-17 IGHD4-23immunoglobulin heavy diversity 4-23 (non-functional) IGHD4-4immunoglobulin heavy diversity 4-4 IGHD5-12immunoglobulin heavy diversity 5-12 IGHD5-18immunoglobulin heavy diversity 5-18 IGHD5-24immunoglobulin heavy diversity 5-24 (non-functional) IGHD5-5immunoglobulin heavy diversity 5-5 IGHD6-13immunoglobulin heavy diversity 6-13 IGHD6-19immunoglobulin heavy diversity 6-19 IGHD6-25immunoglobulin heavy diversity 6-25 IGHD6-6immunoglobulin heavy diversity 6-6 IGHD7-27immunoglobulin heavy diversity 7-27 IGHEimmunoglobulin heavy constant epsilon IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) IGHG3immunoglobulin heavy constant gamma 3 (G3m marker) IGHG4immunoglobulin heavy constant gamma 4 (G4m marker) IGHJ1immunoglobulin heavy joining 1 IGHJ2immunoglobulin heavy joining 2 IGHJ3immunoglobulin heavy joining 3 IGHJ4immunoglobulin heavy joining 4 IGHJ5immunoglobulin heavy joining 5 IGHJ6immunoglobulin heavy joining 6 IGHMimmunoglobulin heavy constant mu IGHV1-12immunoglobulin heavy variable 1-12 (pseudogene) IGHV1-18immunoglobulin heavy variable 1-18 IGHV1-2immunoglobulin heavy variable 1-2 IGHV1-24immunoglobulin heavy variable 1-24 IGHV1-3immunoglobulin heavy variable 1-3 IGHV1-45immunoglobulin heavy variable 1-45 IGHV1-46immunoglobulin heavy variable 1-46 IGHV1-58immunoglobulin heavy variable 1-58 IGHV1-67immunoglobulin heavy variable 1-67 (pseudogene) IGHV1-69immunoglobulin heavy variable 1-69 IGHV1-69-2immunoglobulin heavy variable 1-69-2 IGHV1-69Dimmunoglobulin heavy variable 1-69D IGHV2-26immunoglobulin heavy variable 2-26 IGHV2-5immunoglobulin heavy variable 2-5 IGHV2-70immunoglobulin heavy variable 2-70 IGHV2-70Dimmunoglobulin heavy variable 2-70D IGHV3-11immunoglobulin heavy variable 3-11 IGHV3-13immunoglobulin heavy variable 3-13 IGHV3-15immunoglobulin heavy variable 3-15 IGHV3-16immunoglobulin heavy variable 3-16 (non-functional) IGHV3-20immunoglobulin heavy variable 3-20 IGHV3-21immunoglobulin heavy variable 3-21 IGHV3-23immunoglobulin heavy variable 3-23 IGHV3-30immunoglobulin heavy variable 3-30 IGHV3-33immunoglobulin heavy variable 3-33 IGHV3-35immunoglobulin heavy variable 3-35 (non-functional) IGHV3-38immunoglobulin heavy variable 3-38 (non-functional) IGHV3-43immunoglobulin heavy variable 3-43 IGHV3-48immunoglobulin heavy variable 3-48 IGHV3-49immunoglobulin heavy variable 3-49 IGHV3-53immunoglobulin heavy variable 3-53 IGHV3-6immunoglobulin heavy variable 3-6 (pseudogene) IGHV3-64immunoglobulin heavy variable 3-64 IGHV3-64Dimmunoglobulin heavy variable 3-64D IGHV3-66immunoglobulin heavy variable 3-66 IGHV3-7immunoglobulin heavy variable 3-7 IGHV3-72immunoglobulin heavy variable 3-72 IGHV3-73immunoglobulin heavy variable 3-73 IGHV3-74immunoglobulin heavy variable 3-74 IGHV4-28immunoglobulin heavy variable 4-28 IGHV4-34immunoglobulin heavy variable 4-34 IGHV4-39immunoglobulin heavy variable 4-39 IGHV4-4immunoglobulin heavy variable 4-4 IGHV4-59immunoglobulin heavy variable 4-59 IGHV4-61immunoglobulin heavy variable 4-61 IGHV5-51immunoglobulin heavy variable 5-51 IGHV6-1immunoglobulin heavy variable 6-1 IGHV7-4-1immunoglobulin heavy variable 7-4-1 IGHV7-81immunoglobulin heavy variable 7-81 (non-functional) IGKCimmunoglobulin kappa constant IGKJ1immunoglobulin kappa joining 1 IGKJ2immunoglobulin kappa joining 2 IGKJ3immunoglobulin kappa joining 3 IGKJ4immunoglobulin kappa joining 4 IGKJ5immunoglobulin kappa joining 5 IGKV1-12immunoglobulin kappa variable 1-12 IGKV1-16immunoglobulin kappa variable 1-16 IGKV1-17immunoglobulin kappa variable 1-17 IGKV1-27immunoglobulin kappa variable 1-27 IGKV1-33immunoglobulin kappa variable 1-33 IGKV1-35immunoglobulin kappa variable 1-35 (pseudogene) IGKV1-37immunoglobulin kappa variable 1-37 (non-functional) IGKV1-39immunoglobulin kappa variable 1-39 IGKV1-5immunoglobulin kappa variable 1-5 IGKV1-6immunoglobulin kappa variable 1-6 IGKV1-8immunoglobulin kappa variable 1-8 IGKV1-9immunoglobulin kappa variable 1-9 IGKV1D-12immunoglobulin kappa variable 1D-12 IGKV1D-13immunoglobulin kappa variable 1D-13 IGKV1D-16immunoglobulin kappa variable 1D-16 IGKV1D-17immunoglobulin kappa variable 1D-17 IGKV1D-33immunoglobulin kappa variable 1D-33 IGKV1D-37immunoglobulin kappa variable 1D-37 (non-functional) IGKV1D-39immunoglobulin kappa variable 1D-39 IGKV1D-42immunoglobulin kappa variable 1D-42 (non-functional) IGKV1D-43immunoglobulin kappa variable 1D-43 IGKV1D-8immunoglobulin kappa variable 1D-8 IGKV2-24immunoglobulin kappa variable 2-24 IGKV2-28immunoglobulin kappa variable 2-28 IGKV2-30immunoglobulin kappa variable 2-30 IGKV2-40immunoglobulin kappa variable 2-40 IGKV2D-24immunoglobulin kappa variable 2D-24 (non-functional) IGKV2D-26immunoglobulin kappa variable 2D-26 IGKV2D-28immunoglobulin kappa variable 2D-28 IGKV2D-29immunoglobulin kappa variable 2D-29 IGKV2D-30immunoglobulin kappa variable 2D-30 IGKV2D-40immunoglobulin kappa variable 2D-40 IGKV3-11immunoglobulin kappa variable 3-11 IGKV3-15immunoglobulin kappa variable 3-15 IGKV3-20immunoglobulin kappa variable 3-20 IGKV3-7immunoglobulin kappa variable 3-7 (non-functional) IGKV3D-11immunoglobulin kappa variable 3D-11 IGKV3D-15immunoglobulin kappa variable 3D-15 IGKV3D-20immunoglobulin kappa variable 3D-20 IGKV3D-7immunoglobulin kappa variable 3D-7 IGKV4-1immunoglobulin kappa variable 4-1 IGKV5-2immunoglobulin kappa variable 5-2 IGKV6-21immunoglobulin kappa variable 6-21 (non-functional) IGKV6D-21immunoglobulin kappa variable 6D-21 (non-functional) IGKV6D-41immunoglobulin kappa variable 6D-41 (non-functional) IGLC1immunoglobulin lambda constant 1 IGLC2immunoglobulin lambda constant 2 IGLC3immunoglobulin lambda constant 3 (Kern-Oz+ marker) IGLC4immunoglobulin lambda constant 4 (pseudogene) IGLC7immunoglobulin lambda constant 7 IGLJ1immunoglobulin lambda joining 1 IGLJ2immunoglobulin lambda joining 2 IGLJ3immunoglobulin lambda joining 3 IGLJ4immunoglobulin lambda joining 4 (non-functional) IGLJ5immunoglobulin lambda joining 5 (non-functional) IGLJ6immunoglobulin lambda joining 6 IGLJ7immunoglobulin lambda joining 7 IGLV1-36immunoglobulin lambda variable 1-36 IGLV1-40immunoglobulin lambda variable 1-40 IGLV1-44immunoglobulin lambda variable 1-44 IGLV1-47immunoglobulin lambda variable 1-47 IGLV1-50immunoglobulin lambda variable 1-50 (non-functional) IGLV1-51immunoglobulin lambda variable 1-51 IGLV10-54immunoglobulin lambda variable 10-54 IGLV11-55immunoglobulin lambda variable 11-55 (non-functional) IGLV2-11immunoglobulin lambda variable 2-11 IGLV2-14immunoglobulin lambda variable 2-14 IGLV2-18immunoglobulin lambda variable 2-18 IGLV2-23immunoglobulin lambda variable 2-23 IGLV2-33immunoglobulin lambda variable 2-33 (non-functional) IGLV2-8immunoglobulin lambda variable 2-8 IGLV3-1immunoglobulin lambda variable 3-1 IGLV3-10immunoglobulin lambda variable 3-10 IGLV3-12immunoglobulin lambda variable 3-12 IGLV3-16immunoglobulin lambda variable 3-16 IGLV3-19immunoglobulin lambda variable 3-19 IGLV3-21immunoglobulin lambda variable 3-21 IGLV3-22immunoglobulin lambda variable 3-22 IGLV3-25immunoglobulin lambda variable 3-25 IGLV3-27immunoglobulin lambda variable 3-27 IGLV3-32immunoglobulin lambda variable 3-32 (non-functional) IGLV3-9immunoglobulin lambda variable 3-9 IGLV4-3immunoglobulin lambda variable 4-3 IGLV4-60immunoglobulin lambda variable 4-60 IGLV4-69immunoglobulin lambda variable 4-69 IGLV5-37immunoglobulin lambda variable 5-37 IGLV5-45immunoglobulin lambda variable 5-45 IGLV5-48immunoglobulin lambda variable 5-48 (non-functional) IGLV5-52immunoglobulin lambda variable 5-52 IGLV6-57immunoglobulin lambda variable 6-57 IGLV7-43immunoglobulin lambda variable 7-43 IGLV7-46immunoglobulin lambda variable 7-46 IGLV8-61immunoglobulin lambda variable 8-61 IGLV9-49immunoglobulin lambda variable 9-49 IL10interleukin 10 IL12Ainterleukin 12A IL12Binterleukin 12B IL15interleukin 15 IL18interleukin 18 IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1F10interleukin 1 family member 10 IL1RNinterleukin 1 receptor antagonist IL2interleukin 2 IL3interleukin 3 IL33interleukin 33 IL36Ainterleukin 36 alpha IL36Binterleukin 36 beta IL36Ginterleukin 36 gamma IL36RNinterleukin 36 receptor antagonist IL37interleukin 37 IL4interleukin 4 IL5interleukin 5 IL6interleukin 6 JCHAINjoining chain of multimeric IgA and IgM LTAlymphotoxin alpha MR1major histocompatibility complex, class I-related TLR1toll like receptor 1 TLR10toll like receptor 10 TLR2toll like receptor 2 TLR3toll like receptor 3 TLR4toll like receptor 4 TLR5toll like receptor 5 TLR6toll like receptor 6 TLR7toll like receptor 7 TLR8toll like receptor 8 TLR9toll like receptor 9 TNFtumor necrosis factor TNFRSF13BTNF receptor superfamily member 13B TNFRSF13CTNF receptor superfamily member 13C TNFRSF17TNF receptor superfamily member 17 TNFSF13TNF superfamily member 13 TNFSF13BTNF superfamily member 13b ZBTB12zinc finger and BTB domain containing 12
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