MRLN Gene Summary [Human]
This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]
Details
| Type | Protein Coding |
| Official Symbol | MRLN |
| Official Name | myoregulin [Source:HGNC Symbol;Acc:HGNC:48649] |
| Ensembl ID | ENSG00000227877 |
| Bio databases IDs | |
| Aliases | myoregulin, muscle specific 1, muscle enriched RNA 1, Linc-RNA activator of myogenesis |
| Synonyms | 2310015B20Rik, LINC00948, Linc-RAM, LOC100509305, M1, MLN, MUSER1, myoregulin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme inhibitor activity
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcoplasmic reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRLN gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- enzyme inhibitor activity