LMCD1 Gene Summary [Human]
This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | LMCD1 |
| Official Name | LIM and cysteine rich domains 1 [Source:HGNC Symbol;Acc:HGNC:6633] |
| Ensembl ID | ENSG00000071282 |
| Bio databases IDs | |
| Aliases | LIM and cysteine rich domains 1, dyxin |
| Synonyms | dyxin, LIM and cysteine-rich domains 1, LIMD1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMCD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- PET domain
- protein binding
- cysteine rich domain
- PET (Prickle Espinas Testin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung metastasis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- narcolepsy with cataplexy
- Duchenne muscular dystrophy
- Huntington disease
- myotonic dystrophy
- peripheral arterial disease
- diverticular disease
role in cell
- expression in
- proliferation
- activation in
- accumulation
- migration
- accumulation in
- differentiation
- assembly
- assembly in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMCD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cardiac muscle hypertrophy
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription corepressor activity