NR1D1 Gene Summary [Human]
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | NR1D1 |
| Official Name | nuclear receptor subfamily 1 group D member 1 [Source:HGNC Symbol;Acc:HGNC:7962] |
| Ensembl ID | ENSG00000126368 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1 group D member 1 |
| Synonyms | A530070C09Rik, c-Erb, EAR1, hRev, nuclear receptor subfamily 1 group D member 1, nuclear receptor subfamily 1, group D, member 1, R75201, REVERB, REVERBA, REV-ERBAALPHA, Rev-Erb alpha, Rev-Erba α, Rev-Erb α, THRA1, THRAL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR1D1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A-box
- transcription regulator
- steroid hormone receptor
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription factor binding
- protein binding
- heme binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
- T-box domain
Pathways
Biological processes and signaling networks where the NR1D1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- diabetic nephropathy
- cervical cancer
- Huntington disease
- high-fat diet-induced obesity
- mania
- Duchenne muscular dystrophy
- Hutchinson-Gilford progeria syndrome
role in cell
- quantity
- expression in
- apoptosis
- function
- proliferation
- migration
- number
- differentiation
- survival
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- dendritic spines
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR1D1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- circadian temperature homeostasis
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- steroid hormone mediated signaling pathway
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- cellular response to tumor necrosis factor
- proteasomal protein catabolic process
- intracellular receptor mediated signaling pathway
- positive regulation of bile acid biosynthetic process
- regulation of circadian sleep/wake cycle
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of inflammatory response
- response to leptin stimulus
- regulation of fat cell differentiation
- protein destabilization
- glycogen biosynthetic process
- cellular glucose homeostasis
- cellular response to lipopolysaccharide
- cellular response to interleukin-1
- cell differentiation
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- nuclear body
- cytoplasm
- dendritic spine
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- heme binding
- transcription corepressor binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- E-box binding