AMY2A Gene Summary [Human]
This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | AMY2A |
| Official Name | amylase alpha 2A [Source:HGNC Symbol;Acc:HGNC:477] |
| Ensembl ID | ENSG00000243480 |
| Bio databases IDs | |
| Aliases | amylase alpha 2A |
| Synonyms | AMY2, amylase alpha 2A, amylase α 2A, PA |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMY2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Alpha amylase catalytic domain family
- calcium ion binding
- Alpha amylase, catalytic domain
- enzyme
- Alpha amylase, C-terminal all-beta domain
- alpha-amylase
- Maltogenic Amylase, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- COVID-19
- sepsis
- diabetes mellitus
- septic shock
- impaired glucose tolerance
- age-related macular degeneration
- scurvy
- colorectal cancer
- non-insulin-dependent diabetes mellitus
regulated by
- ascorbic acid
- acarbose
regulates
- polysaccharide
- carbohydrate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMY2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- carbohydrate catabolic process
- polysaccharide digestion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- alpha-amylase activity
- chloride ion binding
- calcium ion binding