PRR5-ARHGAP8 Gene Summary [Human]

The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010]

Details

Type
Protein Coding
Official Symbol
PRR5-ARHGAP8
Official Name
PRR5-ARHGAP8 readthrough [Source:HGNC Symbol;Acc:HGNC:34512]
Ensembl ID
ENSG00000248405
Bio databases IDs NCBI: 553158 Ensembl: ENSG00000248405
Aliases PRR5-ARHGAP8 readthrough
Synonyms PRR5-ARHGAP8 readthrough
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRR5-ARHGAP8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RhoGAP domain
  • Domain in homologues of a S
  • Divergent CRAL/TRIO domain
  • CRAL/TRIO domain
  • GTPase-activator protein for Rho-like GTPases
  • RhoGAP

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • orofacial cleft

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene-Specific Assays for Results You Can Trust

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