CYGB Gene Summary [Human]

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

Details

Type
Protein Coding
Official Symbol
CYGB
Official Name
cytoglobin [Source:HGNC Symbol;Acc:HGNC:16505]
Ensembl ID
ENSG00000161544
Bio databases IDs NCBI: 114757 Ensembl: ENSG00000161544
Aliases cytoglobin, stellate cell activation-associated protein, histoglobin
Synonyms 3110001K20Rik, CYTOGLOBIN, Glnf, HGB, NOD, Staap, STAP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYGB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Globin
  • oxygen binding
  • fatty acid peroxidase
  • protein binding
  • heme group oxidoreductase
  • heme binding
  • catalase
  • nitrogenous compound oxidoreductase
  • superoxide dismutase
  • peroxidase
  • binding protein
  • Globin-like protein superfamily
  • transporter

Pathways

Biological processes and signaling networks where the CYGB gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • cognitive impairment
  • organismal death
  • polycystic kidney disease
  • glioma
  • glioma formation
regulated by
  • JUN
  • halofuginone
  • TP63
  • BDNF
  • thioacetamide
  • FGF2
  • podocytes
  • diethylstilbestrol
  • SP600125
  • pyruvaldehyde
regulates
role in cell
  • production in
  • expression in
  • proliferation
  • apoptosis
  • migration
  • ferroptosis
  • colony formation
  • bortezomib sensitivity
  • respiration
  • peroxidation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • cytosol
  • nuclear speckles
  • neurites
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CYGB gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • response to oxidative stress
  • negative regulation of collagen biosynthetic process
  • response to hypoxia
  • fatty acid oxidation
  • oxygen transport
  • removal of superoxide radicals
  • negative regulation of hepatic stellate cell activation
  • nitric oxide catabolic process
  • negative regulation of fibroblast migration

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • cytosol
  • neuronal cell body
  • neuron projection

Molecular Function

What the gene product does at the molecular level
  • peroxidase activity
  • oxygen binding
  • protein binding
  • iron ion binding
  • oxidoreductase activity
  • catalase activity
  • fatty acid peroxidase activity
  • carbon monoxide binding
  • superoxide dismutase activity
  • oxygen transporter activity
  • heme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.