TUNAR Gene Summary [Human]
Predicted to act upstream of or within several processes, including positive regulation of chromatin binding activity; positive regulation of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TUNAR |
| Official Name | TCL1 upstream neural differentiation-associated RNA [Source:HGNC Symbol;Acc:HGNC:44088] |
| Ensembl ID | ENSG00000250366 |
| Bio databases IDs | |
| Aliases | TCL1 upstream neural differentiation-associated RNA, Tcl1 upstream neuron-associated lincRNA, Human Islet Long Non Coding RNA 78, beta cell- and neural cell-regulin |
| Synonyms | 2810011L19Rik, BNLN, Gm2705, HI-LNC78, LINC00617, LOC100046371, Mi-Lnc78, pTUNAR, Tcl1 upstream neural differentiation associated RNA, transmembrane neural differentiation associated intracellular calcium regulator, TUNA |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUNAR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- metastasis
- Huntington disease
role in cell
- expression in
- differentiation
- motility
- invasion by
- pluripotency
- sphere formation
- morphogenesis
- epithelial-mesenchymal transition
- commitment
- calcium homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUNAR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection morphogenesis
- cytosolic calcium ion homeostasis
- negative regulation of neuron differentiation
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- endoplasmic reticulum calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATPase binding